Choosing among audio interfaces with four inputs is easier when you focus on your actual recording setup rather than headline specifications. Four-input models can handle bands, interviews, multiple microphones, stereo instruments, and more demanding home-studio workflows.
This roundup compares 10 options across key considerations such as preamp quality, connectivity, monitoring, software, portability, and value, so you can find the right fit for your studio or content-creation setup.
Best 10 Audio Interfaces with Four Inputs Picks for 2026
Best Budget 4-Input Interface
- Four MIDAS mic preamps with phantom power
- 4x4 USB audio/MIDI connectivity
- 24-bit/192 kHz support and metal chassis
Best For: Home studios needing four mic-capable inputs and MIDI
Best All-Around 4-Input Interface
Focusrite Scarlett 4i4 4th Gen
- Two mic preamps and two Hi-Z inputs
- Four line outputs with MIDI I/O
- Auto Gain, Clip Safe, and Air modes
Best For: Flexible home studios using microphones, instruments, and line gear
Best for Creators
- Four inputs with two combo XLR connections
- Loopback, dual headphone outputs, and MIDI
- Includes creative software and a five-year warranty
Best For: Content creators and beginners recording voices, guitars, and synths
Best for Podcast Monitoring
CIXUN B-004 4x4 USB-C Interface
- Four combo inputs and four balanced outputs
- Dual-group phantom power and two headphone controls
- Built-in reverb/delay effects for monitoring
Best For: Podcasts, streams, and collaborative recording sessions
Best Portable 4-Input Interface
- Four combo inputs with low-noise preamps and phantom power
- Music/Streaming modes, direct monitoring, and loopback
- USB-C or two-AA battery power for portable recording
Best For: Portable recording, livestreaming, and multi-source setups
Best Pro-Recording 4-Input Interface
- Four MAX-HD preamps with up to 75 dB of gain
- 24-bit/192 kHz recording with low-latency drivers
- Includes Studio One Pro and Auto Gain
Best For: Home studios, guitarists, and low-latency production
Best Compact 2-Input/4-Output Interface
- Two combo inputs and four outputs in a compact design
- 24-bit/192 kHz recording with zero-latency monitoring
- Phantom power, PAD switches, and USB-C connectivity
Best For: Solo recording, podcasting, and flexible monitoring
Best Studio Expansion
Focusrite Scarlett 18i16 4th Gen
- Four mic preamps plus Hi-Z, line, ADAT, S/PDIF, and MIDI I/O
- 24-bit/192kHz conversion with 122dB dynamic range
- Auto Gain, Clip Safe, Air modes, and included software
Best For: Expanding production studios needing flexible routing
Best DSP Monitoring
- Four combo inputs with Class-A D-PRE preamps and phantom power
- DSP monitoring includes reverb, channel strip, and amp effects
- 32-bit/192kHz audio, MIDI, and Windows/macOS/iOS support
Best For: Musicians wanting low-latency effects while tracking
Best Budget 4-Input Interface – Behringer UMC404HD
If you need audio interfaces with four inputs for recording several microphones or instruments, the Behringer UMC404HD offers a straightforward 4-in/4-out USB setup. It combines four MIDAS-designed mic preamps, 24-bit/192 kHz support, MIDI I/O, and a durable metal chassis.
Best For: Home studios and musicians who want four mic preamps, MIDI connectivity, and broad recording-software compatibility.
Pros:
- Four MIDAS-designed mic preamps with +48V phantom power
- 4×4 USB audio and MIDI connectivity with ultra-low latency
- Supports up to 24-bit/192 kHz audio resolution
- Impact-resistant metal chassis
Cons:
- The supplied notes list compatibility with Windows XP or higher and Mac OS X, which may not describe current operating-system support.
- Its 11.5-inch depth is larger than some compact four-input interfaces.
The UMC404HD is a practical choice when four microphone-capable inputs matter more than newer convenience features. Its durable construction and MIDI support add flexibility for a traditional home-recording setup.
Best All-Around 4-Input Interface – Focusrite Scarlett 4i4 4th Gen
The Focusrite Scarlett 4i4 4th Gen is one of the more versatile audio interfaces with four inputs, pairing two mic preamps and two Hi-Z instrument inputs with four line inputs and four outputs. Its USB-C connection, 120 dB dynamic range, and included software make it suited to a flexible studio workflow.
Best For: Producers and musicians recording microphones, guitars, synths, drum machines, and line-level equipment.
Pros:
- Two mic preamps, two Hi-Z inputs, and four line inputs
- Four line outputs plus MIDI input and output
- Auto Gain and Clip Safe help manage recording levels
- Air modes, 24-bit/192 kHz support, and 120 dB dynamic range
Cons:
- Only two of the front-end inputs are mic preamps; the other two are Hi-Z instrument inputs.
- The listed 11-ohm impedance specification may require checking against your particular headphones or setup.
With its varied input types and level-management features, the Scarlett 4i4 is a strong fit for creators who expect their equipment needs to change. The included software bundle also helps new users begin recording quickly.
Best for Creators – Arturia MiniFuse 4
For creators comparing audio interfaces with four inputs, the Arturia MiniFuse 4 stands out with two combo mic/instrument/line inputs and two additional instrument/line inputs. It adds two headphone outputs, USB hubs, MIDI, loopback, and a substantial software package in a compact 1.3-pound design.
Best For: Guitarists, vocalists, content creators, and beginners who want flexible connections and loopback recording.
Pros:
- Four inputs, including two combo XLR inputs with +48V phantom power
- Two independent headphone outputs with volume control
- Loopback supports capturing voiceovers alongside in-app or in-game audio
- Includes MIDI I/O, USB hubs, and extensive creative software
Cons:
- The supplied details identify two inputs as instrument/line TRS rather than additional mic inputs.
- Its listed frequency-response detail is limited to 20 Hz.
The MiniFuse 4 is especially appealing when monitoring, loopback, and beginner-friendly software matter alongside four-input recording. Its five-year warranty and lightweight enclosure add reassurance for portable or evolving setups.
Best for Podcast Monitoring – CIXUN B-004 4×4 USB-C Interface
The CIXUN B-004 is a four-input USB-C interface aimed at multitrack recording, podcasting, and streaming. Its four XLR/TRS combo inputs, dual-group phantom power, built-in reverb/delay effects, and two independently controlled headphone outputs target collaborative monitoring and live content workflows.
Best For: Podcasters, streamers, and small recording teams that want onboard effects and separate headphone control.
Pros:
- Four combo XLR/TRS inputs and four balanced TRS outputs
- 24-bit/192 kHz conversion with Class A preamps
- Independent +48V phantom-power groups for channels 1-2 and 3-4
- Built-in reverb/delay and two independently controlled headphone outputs
Cons:
- The supplied notes do not specify a detailed software bundle or supported recording applications.
- The built-in effects may be unnecessary for users who prefer processing entirely in software.
- A USB-A wall charger is included, so power and computer-connection requirements should be checked for your setup.
The B-004 focuses on hands-on control for live or collaborative use rather than a minimal desktop recording setup. Its dual phantom-power groups and separate headphone controls are useful when different performers need flexible monitoring.
Best Portable 4-Input Interface – Zoom AMS-44
The Zoom AMS-44 is a practical choice for musicians, podcasters, and streamers seeking audio interfaces with four inputs. Its four XLR/TRS combo inputs, four low-noise preamps, and 48V phantom power support flexible recording, while dedicated controls simplify monitoring and livestreaming.
Best For: Musicians and content creators who need four inputs, direct monitoring, loopback, and portable USB-C or battery-powered operation.
Pros:
- Four XLR/TRS combo inputs with four low-noise preamps
- Music and Streaming modes provide flexible routing
- Direct monitoring and loopback work without extra software
- Can run from USB-C or two AA batteries
Cons:
- Its 1-year replacement warranty is shorter than some competing options
- Battery operation requires two AA batteries
The AMS-44 stands out when portability and straightforward streaming controls matter as much as input count. It is especially useful for mobile setups and creators who want to combine computer playback with live inputs without adding software.
Best Pro-Recording 4-Input Interface – PreSonus Quantum ES 4
PreSonus Quantum ES 4 4 x 4, 24-bit / 192 kHz USB-C Audio Interface with Fender Studio Pro Software
Check Price On AmazonThe PreSonus Quantum ES 4 is designed for creators who want audio interfaces with four inputs and a more advanced recording workflow. Four MAX-HD mic preamps offer up to 75 dB of gain, while 24-bit/192 kHz operation, low-latency drivers, and Auto Gain support detailed, efficient sessions.
Best For: Home-studio users, guitarists, and producers who prioritize low-latency recording, high-gain preamps, and broad DAW compatibility.
Pros:
- Four digitally controlled MAX-HD preamps with up to 75 dB of gain
- 24-bit/192 kHz recording and custom low-latency drivers
- Auto Gain simplifies microphone and instrument level setting
- Includes a perpetual Studio One Pro license
Cons:
- At 816 g, it is less lightweight than the Zoom AMS-44
- The feature set may be more than casual users need
With its high-gain preamps, Fender-developed instrument input, and included Studio One Pro license, the Quantum ES 4 is a strong fit for a dedicated recording setup. Its mobile and desktop control options also make it adaptable as your workflow grows.
Best Compact 2-Input/4-Output Interface – BlueAVS AR013
The BlueAVS AR013 is worth considering alongside audio interfaces with four inputs, but its configuration is different: it provides two XLR/TRS combo inputs and four outputs. It focuses on compact recording and streaming, with 24-bit/192 kHz support, zero-latency monitoring modes, phantom power, and instrument PAD switches.
Best For: Podcasters, solo musicians, and streamers who need two recording inputs with flexible four-output monitoring.
Pros:
- 24-bit/192 kHz recording with a 103 dB dynamic range
- Four zero-latency monitoring modes, including mono and stereo
- 48V phantom power and PAD switches support varied sources
- USB-C connectivity works with major Mac and Windows recording software
Cons:
- It has two inputs, not four, so it does not meet a strict four-input requirement
- Its listed frequency response is 20 kHz
The AR013 is a sensible alternative when output flexibility and monitoring are more important than four simultaneous inputs. Its compact design, broad software compatibility, and dedicated controls suit smaller recording and streaming rigs.
Best Studio Expansion – Focusrite Scarlett 18i16 4th Gen
The Focusrite Scarlett 18i16 is a strong choice when shopping for audio interfaces with four inputs and planning to expand beyond basic recording. It combines four mic preamps with Hi-Z, line-level, ADAT, S/PDIF, and MIDI connectivity, giving producers plenty of room for microphones, instruments, and external gear.
Best For: Producers who need four mic preamps today and extensive studio expansion options later.
Pros:
- Offers four mic preamps, two Hi-Z inputs, eight line inputs, ADAT, S/PDIF, and MIDI I/O.
- Supports 24-bit/192kHz recording with 122dB dynamic range converters.
- Includes Auto Gain, Clip Safe, Air modes, and a substantial software bundle.
- Provides 18 inputs and 16 outputs for complex recording and routing setups.
Cons:
- Its broad I/O may be more than a simple four-source home setup requires.
- Requires an external power supply.
The Scarlett 18i16 stands out for its combination of four microphone inputs, high-resolution conversion, and expansion-ready connections. Choose it if your setup is likely to grow or you need substantial routing flexibility.
Best DSP Monitoring – Yamaha URX44C USB-C Interface
The Yamaha URX44C is a practical pick among audio interfaces with four inputs, especially for musicians who want built-in monitoring effects. Its four XLR/TRS combo inputs use Class-A D-PRE preamps, while DSP-powered monitoring adds reverb, channel processing, and guitar amp effects without relying solely on computer processing.
Best For: Musicians and home studios that want four combo inputs, MIDI, and low-latency DSP monitoring.
Pros:
- Includes four XLR/TRS combo inputs with Class-A D-PRE preamps and +48V phantom power.
- Provides two Hi-Z inputs, two line inputs, four line outputs, and two main outputs.
- Offers latency-free DSP monitoring with REV-X reverb, Channel Strip, and Guitar Amp Classics.
- Supports 32-bit integer/192kHz audio, MIDI, and Windows, macOS, and iOS compatibility.
Cons:
- The supplied warranty is one year.
- Its DSP feature set may be unnecessary for users seeking a basic interface.
With four combo inputs and onboard DSP effects, the URX44C is designed for hands-on tracking and monitoring. Its rugged full-metal housing and cross-platform support also suit mobile or frequently moved setups.
Best Budget Four-Channel Starter – Depusheng 4-Channel USB Interface
The Depusheng 4 Channel is a straightforward option for shoppers comparing audio interfaces with four inputs on a home-studio budget. It provides four combo inputs for microphones, guitars, and line sources, along with Hi-Z switches, +48V phantom power, direct/DAW monitoring, and four main outputs.
Best For: Beginners and basic home studios recording several microphones or instruments at once.
Pros:
- Provides four combo inputs with XLR and 1/4-inch connectivity.
- Supports 24-bit/192kHz recording and includes ASIO drivers for low-latency operation.
- Offers Hi-Z switches, +48V phantom power, mono/stereo switching, and direct/DAW monitoring.
- Includes a USB cable, power adapter, and ASIO driver flash drive.
Cons:
- Its listed operating-system compatibility is Windows.
- It has fewer expansion connections than the Focusrite and Yamaha options.
- The supplied warranty is listed as one year.
The Depusheng covers the core requirements for four-channel recording without emphasizing larger studio routing. It is worth considering when you need multiple inputs, phantom power, and ASIO support for a simple PC-based setup.
How We Picked the Best Audio Interfaces with Four Inputs
We selected interfaces that provide four usable inputs or a closely related four-channel recording workflow, while covering a range of budgets and use cases. We considered input flexibility, microphone preamp features, phantom power, maximum sample rate, USB connectivity, MIDI support, monitor outputs, driver and software compatibility, and practical controls for recording and monitoring.
Because specifications do not tell the whole story, we also looked at how each model fits common workflows: recording several microphones, tracking instruments, podcasting, streaming, mobile production, and expanding a home studio. Some products offer exactly four inputs, while others add extra line inputs or outputs for greater flexibility.
Quick Comparison
| Best For | What to Prioritize |
|---|---|
| Home music recording | Quiet preamps, reliable drivers, and flexible combo inputs |
| Podcasting and interviews | Simple gain control, headphone monitoring, and multiple mic support |
| Electronic music and hardware | MIDI, balanced outputs, and enough line-level connectivity |
| Mobile or compact setups | USB-C, bus power, small size, and straightforward controls |
| Growing studios | Expandable I/O, strong routing, and multiple monitor outputs |
Key Buying Factors for Audio Interfaces with Four Inputs
Input Type and Preamp Quality
Combo XLR/TRS inputs are the most versatile because they accept microphones, line-level sources, and many instruments. Check whether all four inputs include microphone preamps or whether some are line-only. If you record quiet dynamic microphones, prioritize adequate gain and low-noise preamps.
Outputs and Monitoring
Four inputs are only useful if the interface can route and monitor them effectively. Look for balanced monitor outputs, independent headphone control, direct monitoring, and enough line outputs for external hardware, multiple monitor pairs, or a headphone amplifier.
Connectivity and Compatibility
USB-C is convenient, but the connector does not automatically determine speed or performance. Confirm operating-system support, driver availability, bus-power requirements, and whether the interface works reliably with your recording software. MIDI ports are valuable when connecting keyboards, drum machines, or other hardware.
Resolution, Latency, and Software
24-bit recording is standard for most projects, while sample rates up to 192 kHz may appeal to specific production workflows. Stable low-latency monitoring is generally more important than the highest number on the specification sheet. Bundled software can also add meaningful value for beginners and producers.
Who Should Buy Which Audio Interfaces with Four Inputs?
Choose a compact four-input interface if you want a portable setup for songwriting, podcasting, or small recording sessions. A model with simple controls and direct monitoring is often the best choice for beginners and spoken-word creators.
For musicians recording several microphones or instruments at once, prioritize four genuine preamp-equipped inputs, dependable gain range, and clear headphone monitoring. Producers using synthesizers or external processors should look for MIDI and multiple balanced outputs.
If you expect your studio to grow, consider an interface with additional line inputs, stronger routing, and more outputs rather than buying strictly for the lowest price. Finally, compare included software, warranty support, and driver reputation before deciding: those practical details can matter more than a marginal difference in sample-rate capability.